The molecule offers the benefits of physical exercise

One molecule has been shown to provide benefits to physical exercise, without the need for physical exercise. However, a miracle pill is far from a reality.

Exercise changes more than 9,800 molecules in our blood, in a process scientists call Cellular “Symphony”. Despite the thousands of molecules involved, not all have the same benefits for the human body.

A team of researchers based at Stanford University School of Medicine in the United States has identified a specific molecule that appears to play a huge role.

The study authors looked at what happens to molecules in the blood plasma of rats after they run on a treadmill until exhaustion.

According to the portal Free Thoughtthe compound C12H14NO4 increased significantly, with researchers later finding that it was N-lactoil-phenylalanine, Where “Lac-Phe”.

The modified amino acid is synthesized from lactic acid – which is produced in abundance during intense physical exercise – and phenylalanine, one of the building blocks of protein.

After experimenting with lab mice, the researchers tested the same thing in race horses is at humans. The results were similar, leading the scientists to conclude that Lac-Phe is the “most significantly induced circulating metabolite.”

To see if this molecule is responsible for mediating some of the “miraculous” health effects of exercise, the researchers put on their lab coats and headed back to the lab.

To this end, they injected Lac-Phe into obese mice, finding that significantly reduced appetite and body fate improved glucose tolerance during the ten-day study period.

Interestingly, Lac-Phe did not confer these benefits on lean, healthy mice. It also did not work when given orally, indicating that Lac-Phe may not work as a “magic pill” of physical exercise.

Lac-Phe further regulated the beneficial effects of physical exercise in a test in which scientists genetically engineered mice lacking a key enzyme to produce Lac-Phe. those mice lost much less weight than mice in the control group.

Potentially, this molecule could reduce the severity of osteoporosis, heart disease, diabetes, cognitive decline and other health issues that exercise is known to help treat.

“Future work uncovering molecular and cellular mediators downstream of the action of Lac-Phe on brain could offer new therapeutic opportunities to capture the cardiometabolic benefits of physical activity for human health. published recently in the magazine Nature.

Daniel Costa, ZAP //

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